Oral Solid Dosage (OSD) forms of anti-diabetic drugs are commonly formulated with metformin as one of the active pharmaceutical ingredients.
Metformin is typically delivered to manufacturing plants in large bags which compacts into hard solid blocks during transport and storage, due to the hygroscopic properties of the material. This means that the product has to be pre-processed into a fine powder prior to milling.
De-agglomeration of metformin significantly improves its flowability and is vital to the success of downstream processes such as milling, mixing and conveying.
This de-agglomeration step can be a time consuming process and cause a bottleneck in production. Finding a solution to the de-lumping of metformin which allows a high throughput can dramatically improve system efficiency.
The Solution: Hanningfield Lump Breaker
The Hanningfield Lump Breaker is designed for the de-agglomeration of compacted material, such as metformin, into smaller particles. Lump breakers can process up to 10,000 kgs/hr (depending on application specifics) and are capable of particle size reduction down to 10mm.
The heavy duty design is available in dual-shaft execution. The cross meshed rotating breaker arms perform size reduction by cutting and shearing the material. The distance between blades can be adjusted according to the required particle size and are easily removed for maintenance or replacement.
Various mounting solutions (e.g. mobile frame) are available and the lump breaker can be customised with a selection of inlet and outlet configurations including hand-feed chute, valve assemblies, tri-clover connections, vacuum adaptors or any other bespoke design required for process integration.
All equipment can be supplied with full validation documentation (FS/DS, FAT, SAT, IQ/OQ) and 3.1 mill certificates to EN10204.
Features
> Stainless steel construction with FDA compliant seals
> No metal-to-metal contact
> Optional sizing grid for achieving smaller particles
> ATEX (ex-proof) versions available
> 2.2kW motor set to a speed of 200RPM (variable speed available)
> 450mm x 558mm inlet and outlet connections (rectangular flange with bolt holes)
Benefits
> High throughput solution for breaking agglomerated material
> Perfect for pre-milling by reducing particle to manageable size
> Can be mounted in-line for feeding downstream process (gravity feed or vacuum transfer)
> Breaker bars can be removed for easy clean
To find out more about Hanningfield’s Lump Breaker, or to request a quotation, send us a message using our Contact Us form.
Get in Touch
If you would like to speak to one of our experts regarding our Lump Breakers or you would like a quote for one of our products, send us a message using our Contact Form or call us on +44 (0)1702 549 777.
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