Industry Blog

Lump Breaker

Features

• Stainless steel construction
• Low maintenance, easy-clean design
• Compact Size
• Low mounting space
• External outbound bearings
• ATEX Versions available

Technical Specification

• Throughput: Up to 10,000 kgs/hr
• Inlet dimensions: 450mm x 550mm
• Motor Power: 2.2kW

Colin Ellis

Product Profile

The size reduction of agglomerated bulk material is imperative to the success of various processes such as milling and sieving. The SureBreak disperses large particles reducing the strain on downstream process equipment, enabling efficient operation without overloading. Moreover, pre-breaking is ideal for size reduction into machines with inlets too small to accept material in large pieces.

The SureBreak lumpbreaker features either single or double shafts with rotating breaker-arms. The breaker arms cross mesh with stationary breaker bars mounted on the inside of the lump breaker machine.

The SureBreak lump breaker is a low speed machine that reduces the product by a cutting and sheering action. Furthermore, no grinding takes place during the size reduction process, resulting in no heat generation, less noise and no metal-to-metal contact.

Agglomerated material is fed into the SureBreak and is forced between the breaker arms where it is crushed into smaller particles. By selection of the number and size of breakers, it is possible to select a suitable finished product. The SureBreak can be used for a variety of applications across the pharmaceutical, food, chemical and associated industries.

The lump breaker is designed and manufactured by Hanningfield in the United Kingdom.

Hanningfield’s Commitment to Quality

Hanningfield’s ‘commitment to quality’ lies at the heart of our success. From manufacturing to maintenance, both our engineers and support staff ensure that we provide the levels of quality customer’s appreciate and which we pride ourselves upon. Attention to detail and reliability are essential to the process industries and Hanningfield strives to focus on this accordingly.

The pharmaceutical and allied industries face rigorous quality guidelines. To ensure we can continually meet the needs of our customers, Hanningfield demonstrates a commitment to quality through certification to the internationally recognised Quality Management System (QMS) Standard ISO 9001.  Moreover, our products can help customers meet their productivity and quality initiatives, such as those of six sigma and lean manufacturing, which have been successfully adopted in the process industries.  Since our original adoption of QMS as a benchmark for maintaining quality in 1995, Hanningfield has been successfully audited on an annual basis by external commissioners.

Hanningfield recognises the importance of innovation, constantly striving to develop new technology to offer our customers. This allows us to constantly improve the capabilities of our existing product range, whilst simultaneously introducing groundbreaking new products; both of which offer significant added value to our customers, who benefit from the pioneering nature of our technology.

Drug companies deal to save taxpayers $1bn

The PBS (Pharmaceutical Benefits Scheme) is apparently under costs decrease as The Federal Government is alleged to have been in on a deal with a certain drug manufacturers.

The pharmaceutical industry has said to have agreed to decrease an estimated $1 billion on medicine prices because of this scheme, it was also announced that yesterday the government chose to sign a 5 year agreement with further pharmacists that is expected to lower another $1 billion.

Hospira & Javelin Combine.

Pharmaceutical company Hospira Inc. have decided to increase their pain management portfolio by combining with Javelin Pharmaceuticals for $145m.

Javelin will get paid $2.20 a share which averages it out at $145m.

The two companies agreed that Javelin can be lent up to amount of $4.5m to help with managing activities before finalising a merger with Hospira.

Sir Tom McKillop returns to Pharmaceutical Industry

Previous banker Sir Tom McKillop has been given a new £54,000-a-year job.

The past chairman of RBS, Sir Tom has come back to the pharmaceutical industry, which he worked for many years and how he earned his knighthood in 2002.

Sir Tom will sit beside a Belgian prince and other European luminaries on the board of directors for pharmaceutical giant UCB, after taking up his position at an astonishing general meeting on 6 November.

As chairman of RBS, Sir Tom watched over the lead-up to the major corporate failure in UK history, and even apologized to a House of Commons Treasury select committee for RBS’s failure. He also come out about having no qualifications in banking.

The panel of directors for UCB – including Prince Lorenz of Belgium – met just seven times in 2008, and Sir Tom will be salaried £900 for each meeting he attends this year, on top of a base pay of £54,000.

A spokeswoman for the firm was reported as saying that Sir Tom was selected for his “great knowledge in the pharmaceutical world”.

Australian Pharmaceutical Industries: a turnaround story

FULL-line drug distribution hasn’t been a brilliant sector: health minister Nicola Roxon is on a rampage to cut subsidies, there’s been unsettling realignments and constant pressure from cheaper generic drugs as the branded ones come off patent.

Australian Pharmaceutical Industries hasn’t been a brilliant investment generally, but it can’t all be blamed on Canberra’s stance on the Pharmaceutical Benefits Scheme and the community service obligation (CSO) scheme (which subsidises distributors for providing obscure drugs to remote chemists).

We’ve had the impression API wouldn’t still be around had it not been for the competition regulation problems inherent in a rival taking over the company (they’ve tried).

The happier side to the API yarn is that new management has made strides in restoring margins and honing the company’s business strategy, which straddles health and beauty retailing via its Priceline chain, drug wholesaling to captive chemists under its Soul Pattinson and Pharmacy Advice banners and wider distribution to other pharmacies.

API this morning reported a “stronger than expected” (company’s words) net profit of $18.6 million for the full-year to August 31. More importantly, it’s joined the capital raising conga line to raise $150m and restore the stretched balance sheet to the industry average.

API chief Stephen Roche denies the banks forced the company into the placement and the non-renounceable rights issue, which is being done at a 38 per cent discount (patient 25 per cent shareholder Washington H Soul Pattinson has agreed to participate).

“There was no breach of covenants in the last financial year,” he says.

Priceline has proved a desirable asset in tighter times: women, it seems, haven’t forsaken lippie and shampoo but if they can get it cheaper then they will shop around.

Roche says sales have been bolstered by the introduction of a loyalty program, Club Card. Three million customers have signed up compared to MyerCard’s 3.2 million — and Priceline doesn’t have the Jennifer Hawkins factor.

According to Roche, Club Card holders account for 40 per cent of retail revenue and spend an average 30 per cent more than other punters.

On the distribution side, margins are still inadequate but the company claims to have won profitable market share.

Roche is sanguine about the current negotiations between the Pharmacy Guild and government over a new five-year agreement which will re-set the terms of full-service drug distribution.

“My personal view is the government wishes the CSO to remain intact … I don’t see fundamental industry change.”

The government, he notes, has priorities other than taking on the renowned force of the pharmacy lobby.”

If Criterion were an existing API holder he would take up the rights. Finally, a turnaround is in the offing.

Source: www.theaustralian.news.com.au

Students help Pfizer improve their process

Rowan University (Glassboro, N.J.) chemical engineering students may help make a drug that eases the pain of arthritis sufferers gentler on the environment.
 
Rowan students Anthony Furiato, Kyle Lynch and Timothy Moroz have been working with Pfizer Inc. to improve the environmental profile of the manufacturing process for the active ingredient in the top-selling arthritis pain medication Celebrex (celecoxib).
 
Working with scientists and engineers from Pfizer’s Global Manufacturing Division headquarters in New York City, its Global Engineering group in Peapack, N.J., and its manufacturing site in Barceloneta, Puerto Rico, the student team is evaluating alternative approaches for solvent recovery. The objective is to reduce the net quantity of solvent waste from the manufacturing process. The Rowan team has been working with several Pfizer personnel, including Dr. Daniel R. Pilipauskas (director/team leader, Active Pharmaceutical Ingredient Development Team), Frank J. Urbanski (director, Engineering Technology), Greg Hounsell (senior manager, Process Engineering) and Jorge Belgodere (manager/team leader, Manufacturing).
 
The project is one of several Rowan engineering clinic projects in which students are exploring green manufacturing strategies for pharmaceutical companies in the region. Started with funding from the U.S. Environmental Protection Agency in 2005, the Rowan “green” partnerships are seeking to improve process efficiency through green engineering design. Pfizer is sponsoring this clinic project through its Green Chemistry initiative. Drs. Mariano Savelski and C. Stewart Slater, of Rowan University, are advisors of the student clinic team.
 
“Most of the clinic projects have students working with an engineer from one corporate site, but in our project students have interacted with Pfizer scientists and engineers from manufacturing in New York City, engineering in New Jersey and plant operations in Puerto Rico,” Savelski said. Students presented their mid-term results in January to Pfizer management in New York City.
 
“Student work to date has been quite impressive. Their ideas for various processes are beneficial to us as we explore alternative methods for waste minimization to improve the environmental footprint of the process and make the operation more economical,” said Pfizer’s Hounsell.
 
Urbanski added, “In addition to providing the students an opportunity to apply their newly acquired engineering skill-base to a very real situation, I suspect the project also gave the students some perspective on the unique challenges faced by engineers in the pharmaceutical industry that will be of value to them as they begin their professional careers.”
 
“Working with the Rowan team, we have been able to explore many options and get to potential solutions quickly. Given that we are engaged with many such projects around the world, working with Rowan has been a valuable experience,” Pilipauskas said.
 
Students are in frequent contact with engineers at Pfizer to exchange ideas and solicit help with their project.
 
“This project provides Pfizer with several design strategies for recovery of the process solvent, used in the production of the drug, from waste streams,” Slater said. “We hope Pfizer can adopt these to make a more efficient process that reduces waste, energy and overall cost.”
 
The students are using computer simulations to predict the performance of their proposed solvent recovery operating schemes. Some of the separation methods the team is considering are distillation, extraction, membrane pervaporation and molecular sieve adsorption. They also are using a computer model to show how recovering the solvent improves the environmental footprint of the process and reduces greenhouse gas emissions.
 
Savelski and Slater were invited speakers at the Pfizer Solvent Operations Network conference in Peapack in February. They shared their expertise in solvent recovery with engineers from locations in Ireland, Puerto Rico, Singapore, the United Kingdom and the United States.
 
The Rowan group will present its work at the 12th Green Chemistry and Engineering Conference in Washington, D.C., in June.
 
As for the future, Pfizer and Rowan project coordinators are discussing how to capitalize on this year’s success in further developing their partnership.

(Source: http://www.reliableplant.com/Article.aspx?articleid=12078)

‘Pharma companies aren’t profiteering’

Drug costs are regularly criticised as being too high - and the pharmaceutical industry attacked for not making them cheaper. But David Fisher, commercial director for the Association of the British Pharmaceutical Industry, says companies are unfairly attacked.

No one can fail to be moved by the experiences of cancer patients who are literally dying for the latest medicines.
My own father succumbed to cancer in 1993, and everyone who has been through that experience knows how patients and families are desperate for any help which will provide them with hope for the future.
But tough decisions have to be made - by the National Institute for Health and Clinical Excellence (the NHS drugs watchdog), NHS executives and patients and their families who wonder if they should use up their life savings paying for medicines which have been rejected by NICE.
 
 
Vilified
 
The pharmaceutical industry, the people who discover and make the medicines which can add precious months and years to the lives of terminally-ill cancer patients, face a different kind of angst.
They risk millions upon millions of pounds in order to find new medicines to treat people who are sick and dying and for whom there is currently no treatment.
The odds of success are almost “impossible”.
If they are successful, the companies have to make enough money to recoup their investment and then fund increasingly expensive research and development in order to find the medicines of the future
 
In the process, they are often vilified as profiting from ill-health.
As an executive within the pharmaceutical industry, I want to stand up for my colleagues.
There is often concern about the price of medicines and their cost to the NHS in relation to the other calls on its £100 billion budget.
Department of Health figures show that 12% of total NHS expenditure goes on medicines, yet it sometimes feels like this is the area which gets all the attention.
We are fortunate in the UK, that the existence of a national health service allows us to “pool” or share our risk (or cost).
This means that we can balance the high cost of some medicines, particularly those for rare diseases, against the lower cost for the majority of medicines.
‘Significant hurdles’
It is the Department of Health’s (DH) role to control prices, and this is done by what is known as the Pharmaceutical Price Regulation Scheme (PPRS).
In short, this limits the profit that pharmaceutical companies can make and the department has the ability to implement periodic price cuts.
The price of medicines in the UK has been reduced by 7% in 2005, a further 3.9% this year, and will decrease by a further 1.9% next year.
Each 1% reduction in the price of branded medicines saves the NHS roughly £80m per year.
Under this scheme companies are in theory free to set prices for some new medicines when they are first licensed, but NICE sets significant hurdles for prices.
Prices in the UK are amongst the lowest in Europe, and we spend far less on medicines than our European neighbours.
Revlimid, a treatment for bone marrow cancer, was a good example (and there are others) where manufacturers have shown flexibility in pricing in the UK, despite the fact that the same medicines are widely available to patients elsewhere in Europe and often at higher prices.
No-one is arguing that pharmaceutical companies should not demonstrate the value for money which their medicines deliver so that NHS can strike the right balance. That is perfectly proper.
But when it comes to considering the balance to be struck, we need to remember that recent price cuts have contributed billions to NHS savings, and in comparison to other countries where new medicines are often more readily available to patients, UK prices are low, total spend is low, and the cost per prescription is low and falling.

Pharmaceutical-Funded Education Draws Congressional Ire

Pharmaceutical industry influence over the information doctors receive in the classroom has more than tripled in the last decade, to $1.2 billion, making it hard to determine whether medical professionals are learning science or getting fed marketing gimmicks, doctors and health professionals told a Senate panel Wednesday.

In a practice called Continuing Medical Education, or CME, doctors take classes and training courses to stay current on the best ways to treat patients. Many states and hospitals require doctors to take such classes. The problem, as Congress and some health professionals see it, is that the pharmaceutical industry now funds more than half these courses, at the pace of $1.2 billion a year.

“CME has become an insidious vehicle for the aggressive promotion of drugs and medical devices,” said Dr. Steve Nissen, a cardiologist from the Cleveland Clinic who is best known for first raising concerns about heart attacks associated with the blockbuster diabetes drug Avandia.

Lewis Morris, chief counsel for the Department of Health and Human Services Office of Inspector General, said there are numerous examples where companies have used CME courses to promote off-label uses of their products, which is illegal.

money.cnn.com

Manufacturers avoid worst.

The pharmaceutical industry has headed off the threat of more onerous imposed cost savings by stepping up to the plate on healthcare reform in the all-important U.S. market.

A weekend deal, announced by President Barack Obama, offering some $80 billion in prescription discounts over 10 years to help elderly Americans afford drugs will crimp profits, but the figure is a less than initially feared.
“Negotiations began with government asking for $130 billion, so $80 billion would represent a relatively benign outcome,” said Savvas Neophytou, an analyst at Panmure Gordon. What’s more, the plan agreed with Senate Finance Committee Chairman Max Baucus, with the backing of the Obama administration, means concessions will be funnelled in an area that could generate additional sales volume.
Drugmakers have agreed to provide a 50 percent discount for those elderly and disabled Americans in the Medicare health insurance program who face a gap in coverage after their drug costs reach a certain level, known as the “doughnut hole”.
“Roughly 20-25 percent of Medicare D patients reach the doughnut hole, and the majority of them either stop or switch their medications,” Deutsche Bank analyst Barbara Ryan said in a research note.
“Therefore, pharma may be providing discounts for branded drugs which will primarily represent incremental demand.”
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